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Purdue School of Engineering and Technology

Purdue School of Engineering and Technology

Nilsson Holguin

  • Assistant Professor of Mechanical Engineering
  • Adjunct of Anatomy and Cell Biology
  • ICMH Investigator
Nilsson Holguin

317-278-2642
nholguin@iupui.edu
Professional Website

Education

  • Trinity College, Engineering, B.S., 05/2005
  • Stony Brook University, Biomedical Engineering, M.S., 12/2007
  • Stony Brook University, Biomedical Engineering, Ph.D., 12/2010

Professional Experience

  • Research Instructor, Washington University in St. Louis, 7/2017 - 6/2018
  • Post Doctoral Research Fellowship, Washington University in St. Louis, 7/2011 - 6/2016

Expertise

The Holguin laboratory focuses on the biomechanics and mechanobiology of the spine undergoing adaptation to aging, mechanical forces, injury and pharmaceutical therapies. Dr. Holguin studies how Wnt signaling, a molecular pathway responsible for cell proliferation and matrix production in many musculoskeletal tissues, may be mediated by mechanical forces to either induce degeneration of the intervertebral disc, its maintenance or repair. The techniques used in the laboratory may be molecular (e.g., PCR, qPCR, Western blots, Raman Spectroscopy), histologic (e.g., staining, IHC, fluorochrome histomorphometry), radiographic (e.g., DEXA, microCT), and biomechanical (e.g., spinal-unit tension-compression, indentation).