E. Morris publications

Papers BY THE BUNCH (Zip files of our papers by topic)

ntPET papers (finding temporal information about neurotransmitters via PET and new analysis techniques)
Includes papers by Morris, Normandin, Constantinescu, Fisher

PET Displacement Sensitivity papers (why are BP and change in BP sensitive to timing of tracer and neurotransmitter)
Includes papers by Morrsi & Yoder

PET studies of alcohol effects in humans
Includes papers from Yoder,Kareken, Morris collaboration

Multiple Injection Studies with PET
Includes papers by Morris, Alpert, Christian, Fischman, Muzic, Bonab

RECENT PUBLICATIONS from our group and our collaborations

CC Constantinescu, KK Yoder, DA Kareken, CA Bouman, SJ O'Connor, MD Normandin, ED Morris. (2008) Estimation from PET data of transient changes in dopamine concentration induced by alcohol: Support for a non-parametric signal estimation method. Physics in Medicine and Biology 53: 1353-1367. (unocrrected proof) (Email Evan for printed version)

KK Yoder, CC Constantinescu, MD Normandin, TE Cheng, O'Connor, DA Kareken, ED Morris. (2008) What were they thinking?  Cognitive states may influence [11C]raclopride binding potential in the striatum.  Neurosci Letters. Neurosci Lett. 2008 Jan 3;430(1):38-42. Epub 2007 Dec 3.

MD Normandin and ED Morris. (2007).Estimating neurotransmitter kinetics with ntPET: A simulation study of temporal precision and effects of biased data  Neuroimage.  [Oct 5 Epub ahead of print]. (corrected proof) (Email to Evan for printed vesrion)

Yoder, KK, Constantinescu CC, Kareken DA, Normandin MN, Cheng TN, O'Connor SJ and Morris ED. (2007) Heterogeneous effects of alcohol on dopamine release in the striatum: a PET study. ACER Jun;31(6):965-73. Epub 2007 Apr 11.

C. C. Constantinescu, C. A. Bouman and E.D. Morris. (2007) Nonparametric Extraction of Transient Changes in Neurotransmitter Concentration from Dynamic PET Data.  IEEE Trans Med Imag.  26(3) 359-373.

Morris ED and. Yoder KK.  (2007)  PET Displacement Sensitivity: Predicting Binding Potential Change for PET Tracers Based on their Kinetic Characteristics. J Cereb Blood Flow Metab. 2007 Mar;27(3):606-17. Epub 2006 Jun 21. (See current Newsline in JNM Aug 2006 - we made the news!)

Morris ED, Yoder KK, Wang C, Normandin MD, Zheng Q-H, Mock B, Muzic RF, Froehlich JC.  (2005)  ntPET: A New Application of PET Imaging for Characterizing the Kinetics of Endogenous Neurotransmitter Release.  Molec Imag Vol 4, No 4, pp473-489.  (higher resolution figures in bootleg copy)

James JR, Yoder KK, Osuntokun O, Kalnin A, Bruno A, Morris ED. (2005) A supervised method for calculating perfusion / diffusion mismatch volume in acute ischemic stroke. Comp Biol Med (In Press) Aug 2005 Epub ahead of print.

Yoder KK, Kareken, D Seyoum R, O'Connor S, Wang C, Zheng QH, Mock B, Morris ED.  Dopamine D2 receptor availability is associated with subjective responses to alcohol. (2005) Alc Clin Exp Res. Vol 29, No 6, 2005: pp 965–970

M. Kamasak, C.A. Bouman, E.D. Morris, K. Sauer (2005) Direct Reconstruction of Kinetic Parameter Images from Dynamic PET Data. IEEE Trans Med Imag  24:636-650.

Morris, ED, Christian, BT, Yoder, KK, Muzic, RF.  (2004) "Estimation Of Local Receptor Density B' max and Other Parameter Via Multiple-Injection PET Experiments."   In Methods in Enzymology, Volume 385, Imaging in Biological Research Part A, P. Michael Conn (Ed).  Academic Press.  San Diego. 385:184-213

Yoder, KK  Hutchins, GD  Morris, ED Brashear A Wang, C  Shekhar A. (2004)  Dopamine transporter density in schizophrenic subjects with and without tardive dyskinesia.  Shizophrenia Research 71: 371-375.

Yoder, KK  Wang, C  Morris, ED. (2004) Change in Binding Potential as a Quantitative Index of Neurotransmitter Releaseis Highly Sensitive to Relative Timing and Kinetics of Both the Tracer and the Endogenous Ligand. J Nucl Med. 45(5) 903-911.

Christian, BT Narayanan, T Shi, B  Morris, ED Mantil, J Mukherjee, J.  (2004) Measuring the In Vivo Binding Parameters of [¹⁸F]-Fallypride in Monkeys Using a PET Multiple-Injection Protocol.  J Cereb Blood Flow & Metab Mar;24(3):309-22

Recent CONFERENCE Papers

Normandin MD and Morris ED, Temporal Resolution of ntPET Using Either Arterial or Reference Region-Derived Plasma Input Functions. IEEE Proceedings of 28th Engineering in Medicine and Biology Society Conference, New York (2006) p2005-2008.

Morris, ED, Kamasak ME, Christian BT, Cheng TE, Bouman CA.  Visualizing all the fits: Evaluatung the quality and precision of parametric images crated from direct reconstruction of PET sinogram data. (2006) Proceedings of the IEEE International Symposium on Biomedical Imaging (ISBI), p291-295

Mustafa E. Kamasak, Charles A. Bouman, Evan D. Morris, and Ken Sauer, Reconstruction of kinetic parameter images directly from dynamic {PET} sinograms.  Proc. of SPIE Conf. on Medical Imaging: Image Processing,  February 2005, vol. 5747.

Mustafa E. Kamasak, Charles A. Bouman, Evan D. Morris, and Ken Sauer, Parametric reconstruction of kinetic {PET} data with plasma function estimation. Proc. of SPIE Conf. on Electronic Imaging:  Computational Imaging, January 2005, vol. 5674, pp. 293-305.

JR James, O Osuntokun, K Yoder, A Bruno, ED. Morris, " A Supervised Method For Calculation Of Perfusion/Diffusion Mismatch Volume In Acute Stroke", (2004) Proceedings of the IEEE International Symposium on Biomedical Imaging (ISBI), p1295-1298

M. Kamasak, C.A. Bouman, E.D. Morris, K. Sauer, "Direct Reconstruction of Kinetic Parameter Images from Dynamic PET Data" (2003), Proceedings of the 37^th Asilomar Conference on Signals, Systems, and Computers, 1919-1923.

Some of Evan's OLDER PAPERS etc

JA Matochik, SI Chefer, M.A. Lane,  RI Woolf, ED Morris et al.  (2000):  Age-Related Decline in Striatal Volume in Monkeys as Measured by Magnetic Resonance Imaging. Neurobiol of Aging 21: 591-598.

Morris, ED, SI Chefer, MA Lane, RF Muzic Jr., DF Wong, RF Dannals, JA Matochik, AA Bonab, VL Villemagne, SJ Grant, DK Ingram, GS Roth and ED  London.  (1999): Loss of D2 Receptor Binding with Age in Rhesus Monkeys:  Importance of Correction for Differences in Striatal Size. J Cereb Blood Flow & Metab 19:218-229.   (Try low res version to load faster.)

Morris, E.D., A.A. Bonab, N.M. Alpert, A.J. Fischman, B.K. Madras, B.T. Christian. (1999). Concentration of Dopamine Transporters: To Bmax or Not to Bmax. Synapse 32(2): 136-140.  (Letter responding to Logan et al, 1997, Synapse).

Morris, E.D., J.W. Babich, N.M. Alpert, A.A. Bonab, E. Livni, S. Weise, H. Hsu, B.T. Christian, B.K. Madras, A.J. Fischman.  (1996): Quantification of Dopamine Transporter Density in Monkeys by Dynamic PET Imaging of Multiple Injections of 11C-CFT. Synapse. 24:262-272.

Morris, E.D., N.M. Alpert, A.J. Fischman. (1996): Comparison of Two Compartmental Models for Describing Receptor Ligand Kinetics and Receptor Availability in Multiple Injection PET Studies.  J Cereb Blood Flow & Metab. 16:841-853.

Morris, E.D., R.E. Fisher, N.M. Alpert, S.L. Rauch, A.J. Fischman (1995): In Vivo Imaging of Neuromodulation Using Positron Emission Tomography: Optimal Ligand Characteristics and Task Length for Detection of Activation. Human Brain Mapping. 3:35-55.

Fisher, R.E., E.D. Morris, N.M. Alpert, A.J. Fischman (1995):  In Vivo Imaging of Neuromodulatory Synaptic Transmission Using PET: A Review of Relevant Neurophysiology.  Human Brain Mapping 3:24-34.

Alpert, N.M., D. Berdichevsky, Z. Levin, E.D. Morris, A.J. Fischman (1996): Improved Methods for Image Registration. NeuroImage. 3(1): 10-18.

Morris, E.D., G.J. Muswick, E.S. Ellert, R.N. Steagall, P.F. Goyer, W.E. Semple.  (1993): Computer-Aided Techniques for Aligning Interleaved Sets of Non-Identical Medical Images. Proceedings of the SPIE, Image Processing vol. 1898,  p146-157.

Morris, E.D., G.M. Saidel, G.M. Chisolm (1991):  Optimal design of experiments to estimate LDL transport parameters in arterial wall. Modeling Methodology Forum of Am. J. Physiol. 261 (Heart Circ. Phys. 30) H929-H949.

Saidel, G.M., E.D. Morris, G.M. Chisolm (1987):  Transport of macromolecules in arterial wall in vivo: a mathematical model and analytical solutions. Bull. Math. Biol. 49(2):153-169.

Meeting Papers, Posters
Tasciyan, TA, Beckman CF, Morris ED, Smith SM (2001): ICA-Based Segmentation of the Brain on Perfusion Data.  IEEE EMBS Meeting, Istanbul. (poster)

Morris ED, VanMeter JW, Tasciyan TA, Zeffiro TA (2000): Automated determination of the arterial input function for quantitative MR perfusion analysis. ISMRM Meeting, Denver.

Book Chapters
Morris ED, Endres, CJ , Schmidt K , Christian BT, Muzic RF, and Fisher RE. (2004) "Kinetic Modeling in PET" in Emission Tomography: The Fundamentals of PET and SPECT,  Chapter 23, M Wernick and N Aarsvold eds.  Academic Press. Amsterdam. p499-540.

Morris ED, Muzic RF, Christian BT, Endres, CJ and Fisher RE. (2000) "Modeling of PET/SPECT Receptor Images" in Functional Neuroimaging in Child Psychiatry, M Ernst and J Rumsey eds.  Cambridge University Press, Cambridge, UK.

Morris, E.D., S.I. Chefer, and E.D. London. (1998) "Limitations of Binding Potential as a Measure of Receptor Function.  A Two-Point Correction for the Effects of Mass."  In Quantitative Functional Brain Imaging with Positron Emission Tomography, R.E. Carson, M.E. Daube-Witherspoon, P. Herscovitch eds.
Academic Press, p407-414.

Book Review
Morris, ED,and AJ Fischman(1998):  Review of “Quantitation of Brain Function Using PET”. J Chemical Neuroanatomy 15(4) 262-263.

Accepted/presented conference submissions (recent)  (posters to be added soon)

presented at JMIC in Providence -- 1.    ED Morris, CC Constantinescu, MD Normandin,  WK Schiffer, CA Bouman, KK Yoder, DA Kareken, TE Cheng, SA Berg, RA Chambers.  Toward Noninvasive Temporal Characterization of Drug-Induced Neurotransmitter Release. Development of ntPET Methods for the Study of Drug and Alcohol Abuse. Joint Meeting of AMI/SMI, Providence, Sept. 2007

presented at SNM in DC --  A linear model for characterizing neurotransmitter release dynamics from PET data.  M. D. Normandin, R. D. Badgaiyan, N. M. Alpert, A. J. Fischman and E. D. Morris

presented at SNM in DC --  Validation of a model-independent method for extracting transient changes in neurotransmitter level from dynamic PET C. C. Constantinescu, K. K. Yoder, D. A. Kareken, S. J. O’Connor, M. D. Normandin, C. A. Bouman and E. D. Morris

presented at SNM in DC --  A dual head holder for simultaneous scanning of two rats in IndyPET-II: Design, feasibility and kinetic validation T. Cheng, K. K. Yoder, M. A. Miller, M. D. Normandin, L. A. Corbin and E. D. Morris;

presented at NeuroReceptorMapping in Copenhagen ---Kamasak, ME, Bouman CA, Morris, ED, Christian BT.  Direct reconstruction of parametruc images using 18F-fallypride in non-human primates.  Neuroimage 31, T92, 2006.

presented at EMBC in NY   ---Normandin, M and Morris, ED. Temporal Resolution of ntPET Using Either Arterial of Reference Region-Derived Plasma Input Functions

preseted at BMES in Chicago --- Normandin MD and Morris ED, Estimating Neurotransmitter Kinetics with ntPET: Effects of Constraints or Corrupted Input Functions

preseted at  BMES in Chicago --- CC Constantinescu, C Bouman, and E Morris, Visualization of in vivo dopamine fluctuations via PET imaging and singular value decomposition

preseted at  SFN in Atlanta  ---  Yoder KK, Morris ED, Radnovich AJ, Sean O’Connor, Kareken DA.  Differential effect of alcohol and alcohol cues on ventral striatal dopamine: a [11C]raclopride PET study.

preseted at  SFN in Atlanta  ---   Morris ED, Kareken DA, Radnovich AJ, Sean O’Connor, Yoder KK.   Intravenous alcohol infusion does not induce ventral striatal dopamine release in subjects anticipating alcohol administration.

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